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Medicinal Chemistry Lab.

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Total 148 , Page 1 / 15

Discovery of a peripheral 5HT2A antagonist as a clinical candidate for Metabolic Dysfunction-Associated Steatohepatitis
  • AuthorHaushabhau S. Pagire, Suvarna H Pagire, Byung-kwan Jeong, Won-il Choi, Chang Joo Oh, Chae Won Lim, Minhee Kim, Jihyeon Yoon, Seong Soon Kim, Myung Ae Bae, Jae-Han Jeon, Sungmin Song, Hee Jong Lee, Eun Young Lee, Peter Goughnour, Dooseop Kim, In-Kyu Lee, Rohit Loomba, Hail Kim*, Jin Hee Ahn*
  • Year2024
  • SourceNature Communications 2024, 15, 645

Design, synthesis, and biological evaluation of new 2,6,7-substituted purine derivatives as Toll-like receptor 7 agonists for intranasal vaccine adjuvants
  • AuthorMorgan Kim, Kyungseob Noh, Pyeongkeun Kim, Jaeho Kim, Byeong Wook Choi, Ravi Singh, Junho Choi, Soo Bong Han, Seong Soon Kim, Eun-Young Lee, Myung Ae Bae, Daeho Shin, Meehyein Kim*, Jin Hee Ahn*
  • Year2024
  • SourceJ. Med. Chem. 2024, 67, 9389-9405

Discovery of Novel Arylpyridine Derivatives for Motile Ciliogenesis
  • AuthorGwi Bin Lee, Gopalakrishnan Chandrasekaran, Hee-Joong Kim, Pyeongkeun Kim,, Jihyeon Yoon, Byeong Wook Choi, So-Hyun Lee, Sang-Yong Lee, Dae-Seop Shin, Byung Hoi Lee, Myung Ae Bae, Peter Goughnour, Eun Young Choi, Seok-Yong Choi* and Jin Hee Ahn*
  • Year2024
  • SourceEur J Med Chem 2024, 277, 116764

Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling
  • AuthorJeong-Yun Lee, Suhyeon Park, Eun Jung Park, Haushabhau S. Pagire, Suvarna H. Pagire, Byeong-Wook Choi, Moonyoung Park, Sungsoon Fang, Jin Hee Ahn*, Chang-Myung Oh*
  • Year2024
  • SourceBiomedicine & Pharmacotherapy 2024, 179, 117428

PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
  • AuthorJuhee Kim, Yujin Jeon, Jinyoung Son, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Akiyoshi Uemura, In-Kyu Lee, Sungmi Park* and Dong Ho Park*
  • Year2024
  • SourceCell Death & Disease 2024, 15, 582

Activation mechanism and novel binding sites of the BKCa channel activator CTIBD
  • AuthorNarasaem Lee, Subin Kim1, Na Young Lee, Heeji Jo, Pyeonghwa Jeong, Haushabhau S Pagire, Suvarna H Pagire, Jin Hee Ahn, Mi Sun Jin, Chul-Seung Park*
  • Year2024
  • SourceLife Science Alliance 2024, 7, e202402621

Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease
  • AuthorJihyeon Yoon, Won-Il Choi, Saravanan Parameswaran, Gwi Bin Lee, Byung Wook Choi, Pyungkeun Kim, Dae-Seop Shin, Ha Neul Jeong, Seung Mi Lee, Chang Ju Oh, Jae-Han Jeon, In-Kyu Lee, Myung Ae Bae*, Hail Kim*, Jin Hee Ahn*
  • Year2023
  • SourceBioorg. & Med. Chem. Lett. 2023, 94, 129461

Inhibition of PDK4 ameliorates renal ischemia-reperfusion injury by reducing succinate 3 accumulation during ischemia and preserving mitochondrial function during reperfusion
  • AuthorChang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah Reum Khang, Robert A. Harris, Jin Hee Ahn*, Jae-Han Jeon*, In-Kyu Lee*
  • Year2023
  • SourceKidney International 2023, 104, 724-739

Inhibition of pyruvate dehydrogenase kinase 4 in CD4+ T cells ameliorates intestinal inflammation
  • AuthorHoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee*
  • Year2023
  • SourceCellular and Molecular Gastroenterology and Hepatology 2023, 15, 439-461

Synthesis and Biological evaluation of Tyrosine derivatives as peripheral 5HT2A receptor antagonists for Nonalcoholic Fatty Liver Disease
  • AuthorMinhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In Kyu Lee, Hail Kim,* Jin Hee Ahn*
  • Year2022
  • SourceEur. J. Med. Chem. 2022, 239, 114517
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